Lecture and Exercise Protein Prediction II for Computer Scientists WS18/19

Type:	Lecture (4 SWS) + Exercise (2 SWS)
Ects:	8.0
Lecturer	Burkhard Rost (lecture) Jonas Reeb (exercise) Michael Bernhofer (exercise)
Rotation:	Tuesday, 10:00 - 12:00 Thursday, 10:00 - 12:00 Thursday, (exercise), 12:00 - 13:00
Place:	Lecture: 01.09.034 Exercise: 01.09.034 Exam:
Language:	English
Announcements:	Exam review on Monday, March 18, from 11:00 to 12:00 in room 01.09.034. No exercise on 22.11. No lecture on 13.11 (SVV). The latest news are always on top!
Exam	tba

Content

This lecture continues the 'Protein Prediction I' lecture. The attendance of this lecture however is not a mandatory requirement for 'Protein Prediction II'. Topics will include (but not be limited to):

Predicting protein function using sequence: sequence alignments, multiple sequence alignments, motifs, domain assignment, annotation transfer by homology, ab initio predictions.
Predicting protein function using structure: structural alignments, structural motifs, annotation transfer via structure similarity.
From structure prediction to function prediction: comparative modeling; prediction of: secondary structure, hydrophilicity profiles, solvent accessibility, transmembrane segments, disordered regions, contact maps, functional residues; template free modeling.
Machine learning.