Lecture and Exercise Protein Prediction I for Bioinformaticians SS16

 

Type:

Lecture (4 SWS) + Exercise (2 SWS)

Ects:

8.0

Lecturer

Burkhard Rost  (lecture)
tba (exercise)

Lecture:

Tuesday, 12:00 - 14:00

  • Room: MI 01.09.034 (Rostlab seminar room)

Thursday, 12:30 - 14:00

  • Room: MI 01.09.034 (Rostlab seminar room)

Exercise:

Thursday, 14:00 - 15:30

  • Room: MI 01.09.034 (Rostlab seminar room)

Exam:

Time: 13:00-14.30, Room: MW2001 (Rudolf-Diesel-Hörsaal)

Make-up exam: Time: tba  October 18th, 2016, Room: tba

Language:

English

Announcements:

  • !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!THE LECTURE IS OVER!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! UNFORTUNATELY THE SLIDES THAT MENTION TWO WRAP-UP SESSIONS AFTER JUNE 28 ARE WRONG!!!!! WE APOLOGISE FOR THE INCONVENIENCE
  • Please be aware that some details are currently modfied. Please come back regularly

Content

Topics will include (but not be limited to):

  • Intro: what is protein function?
  • Predicting protein function using sequence: sequence alignments, multiple sequence alignments, motifs, domain assignment, annotation transfer by homology, ab initio predictions.
  • Predicting protein function using structure: structural alignments, structural motifs, annotation transfer via structure similarity.
  • From structure prediction to function prediction: comparative modeling; prediction of: secondary structure, hydrophilicity profiles, solvent accessibility, transmembrane segments, disordered regions, contact maps, functional residues; template free modeling.
  • Machine learning.

Slides:

Exercise:

  • The exercise is managed exclusively through this wiki page that will be maintained throughout the course.
  • Please find all materials and announcements here
  • This page requires log-in information which can be obtained from the tutors during the exercise sessions