Protein Prediction I Beginners (for Computer Scientists) SS15

Type:

Lecture (4 SWS) + Exercise (2 SWS)

Ects:

8.0

Lecturer

Burkhard Rost  (lecture)
tba (exercise)

Lecture:

Tuesday, 10:00 - 11:30

  • Room: MI 01.09.034

Thursday, 10:00 - 11:30

  • Room: MI 01.09.034

First lecture on April 21, 2015.

Exercise:

Thursday, 12:00 - 13:30

  • Rooms: MI 00.04.011 Hörsaal 2

Exam:

Thursday, July 9, 18:30 - 20:00

  • Room: MI HS 1, Friedrich L. Bauer Hörsaal (00.02.001)

Makeup exam: October 13, 18:30 - 20:00

  • Room: HS2

Review for Protein Prediction I Regular Exam is on October 1st at 10.30-11.30. Room: 01.09.058

Language:

English

Announcements:
  • For the lecture as well as later for the exam, please register for the course via TUMonline for "Protein Prediction I for Beginners". The course might be renamed soon to "Protein Prediction I for Computer Scientists"
  • Please be aware that some details are currently modfied. Please come back regularly

Content

Topics will include (but not be limited to):

  • Intro: what is protein function?
  • Predicting protein function using sequence: sequence alignments, multiple sequence alignments, motifs, domain assignment, annotation transfer by homology, ab initio predictions.
  • Predicting protein function using structure: structural alignments, structural motifs, annotation transfer via structure similarity.
  • From structure prediction to function prediction: comparative modeling; prediction of: secondary structure, hydrophilicity profiles, solvent accessibility, transmembrane segments, disordered regions, contact maps, functional residues; template free modeling.
  • Machine learning.

Materials

Lecture:

 

Exercise:

The main information exchange for the exercise is this wiki. The organisation of the exercise is explained there.