Protein Prediction I Advanced (for Bioinformaticians) SS15

Topics will include (but not be limited to):

• Intro: what is protein function?
• Predicting protein function using sequence: sequence alignments, multiple sequence alignments, motifs, domain assignment, annotation transfer by homology, ab initio predictions.
• Predicting protein function using structure: structural alignments, structural motifs, annotation transfer via structure similarity.
• From structure prediction to function prediction: comparative modeling; prediction of: secondary structure, hydrophilicity profiles, solvent accessibility, transmembrane segments, disordered regions, contact maps, functional residues; template free modeling.
• Machine learning.