Protein Prediction I Advanced (for Bioinformaticians) SS15

 
 

Type:

Lecture (4 SWS) + Exercise (2 SWS)

Ects:

8.0

Lecturer

Burkhard Rost  (lecture)
Maximilian Hecht, Jonas Reeb (exercise)

Lecture:

 

Tuesday, 12:30 - 14:00

  • Room: MI 01.09.034

Thursday, 12:30 - 14:00

  • Room:  MI 01.09.034

First lecture April 21

Exercise:

Thursday, 14:00 - 15:30

  • Room: MI 01.09.034

Exam:

Thursday 09.07.15, 13:00 - 15:00, MI 01.09.034, Seminarraum

Language:

English

Announcements:

  • Please be aware that some details are currently modfied. Please come back regularly
  • Exam review (Klausureinsicht) takes place on Wed. 29.09 14:00 in room 01.09.034

Content

Topics will include (but not be limited to):

  • Intro: what is protein function?
  • Predicting protein function using sequence: sequence alignments, multiple sequence alignments, motifs, domain assignment, annotation transfer by homology, ab initio predictions.
  • Predicting protein function using structure: structural alignments, structural motifs, annotation transfer via structure similarity.
  • From structure prediction to function prediction: comparative modeling; prediction of: secondary structure, hydrophilicity profiles, solvent accessibility, transmembrane segments, disordered regions, contact maps, functional residues; template free modeling.
  • Machine learning.

Materials

Lecture:

Exercise:

  • The exercise is managed exclusively through a wiki that will be maintained throughout the course.
  • Please find all materials and announcements here
  • This page requires log-in information which can be obtained from the tutors during the exercise sessions