Lecture and Exercise Protein Prediction I for Bioinformaticians SoSe 18

Type:	Lecture (4 SWS) + Exercise (2 SWS)
ECTS:	8.0
Lecturer	Burkhard Rost (lecture) Maria Schelling (exercise)
Lecture:	Tuesday, 12:30 - 14:00 Room: MI 01.09.034 (Rostlab seminar room) Thursday, 12:30 - 14:00 Room: MI 01.09.034 (Rostlab seminar room)
Exercise:	Thursday, 14:00 - 15:30 Room: MI 01.09.034 (Rostlab seminar room)
Exam:	Thursday, July 12, 18:00- 20:00 MW0001
Make-up exam:	tba
Language:	English
Announcements:	All lectures and exercises start at April 19th

Content

Topics will include (but not be limited to):

Intro: what is protein function?
Predicting protein function using sequence: sequence alignments, multiple sequence alignments, motifs, domain assignment, annotation transfer by homology, ab initio predictions.
Predicting protein function using structure: structural alignments, structural motifs, annotation transfer via structure similarity.
From structure prediction to function prediction: comparative modeling; prediction of: secondary structure, hydrophilicity profiles, solvent accessibility, transmembrane segments, disordered regions, contact maps, functional residues; template free modeling.
Machine learning.