Protein Localization Database for Human and Arabidopsis

 
 
 

Protein Subcellular Localization

LocDB is a expert curated database that collects experimental annotations for the subcellular localization of proteins in Human (Homo sapiens) and Weed (Arabidopsis thaliana). The database also contains predictions of subcellular localization from a variety of state-of-the-art prediction methods for all proteins with experimental information.

Proteins are the fundamental functional components of cells. They are responsible for transforming genetic information into physical reality. These macromolecules mediate gene regulation, enzymatic catalysis, cellular metabolism, DNA replication, and transport of nutrients, recognition, and transmission of signals. The interpretation of this wealth of data to elucidate protein function in post-genomic era is the a fundamental challenge. To date, even for the most well-studied organisms such as yeast, about one-fourth of the proteins remain uncharacterized. Major obstacle in experimentally determining protein function is that the studies require enormous resources. Hence, the gap between the amount of sequences deposited in databases and the experimental characterization of the corresponding proteins is ever-growing. Bioinformatics plays a central role in bridging this sequence-function gap through the development of tools for faster and more effective prediction of protein function. With this repository we are trying to fill the gap between experimental annotations and predictions and providing a bigger dataset for the testing of new prediction methods.

Who are we?

Rostlab: The Rost Group at TU Munich
PP: Predict Protein - protein sequence analysis, structure, function and subcellular localization prediction
LocTree2: Prediction of sub-cellular LOCalization for all domains of life
LOCtree (integrated into PredictProtein) : Prediction of sub-cellular LOCalization for structural genomics targets )
PredictNLS (integrated into PredictProtein): Prediction and analysis of Nuclear Localization Signals
LOCnet: De novo prediction of protein sub-cellular localization





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The basic protein targeting pathways
Click to see the list of all proteins.
 

 

 

 
© Copyright 2008-2016 RostLab. All Rights Reserved. Shruti Rastogi (locdb@rostlab.org)
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