EVA: Evaluation of protein structure prediction servers.

TitleEVA: Evaluation of protein structure prediction servers.
Publication TypeJournal Article
Year of Publication2003
AuthorsY Y Koh, I, Eyrich, VA, Marti-Renom, MA, Przybylski, D, Madhusudhan, MS, Eswar, N, Graña, O, Pazos, F, Valencia, A, Sali, A, Rost, B
JournalNucleic Acids Res
Date Published2003 Jul 1
KeywordsAutomation, Databases, Protein, Internet, Protein Conformation, Protein Folding, Protein Structure, Secondary, Proteins, Reproducibility of Results, Sequence Analysis, Protein, Structural Homology, Protein

EVA (http://cubic.bioc.columbia.edu/eva/) is a web server for evaluation of the accuracy of automated protein structure prediction methods. The evaluation is updated automatically each week, to cope with the large number of existing prediction servers and the constant changes in the prediction methods. EVA currently assesses servers for secondary structure prediction, contact prediction, comparative protein structure modelling and threading/fold recognition. Every day, sequences of newly available protein structures in the Protein Data Bank (PDB) are sent to the servers and their predictions are collected. The predictions are then compared to the experimental structures once a week; the results are published on the EVA web pages. Over time, EVA has accumulated prediction results for a large number of proteins, ranging from hundreds to thousands, depending on the prediction method. This large sample assures that methods are compared reliably. As a result, EVA provides useful information to developers as well as users of prediction methods.

Alternate JournalNucleic Acids Res.
PubMed ID12824315
PubMed Central IDPMC169025
Grant List1-P50-GM62413-01 / GM / NIGMS NIH HHS / United States
5-P20-LM7276 / LM / NLM NIH HHS / United States
P50 GM62529 / GM / NIGMS NIH HHS / United States
R01 GM54762 / GM / NIGMS NIH HHS / United States
R01-GM63029-01 / GM / NIGMS NIH HHS / United States