Evolution teaches prediction
Bioinformatics up to the data deluge? NO, but work in progress!
Know what we do? Some do, 30% over 100 residues!
Where are we today? NO 3D prediction from sequence!
Evolutionary odyssey applied:
- secondary structure +15% -> 76% ± 10%
- transmembrane proteins +10% -> 65% topo ok
- solvent accessibility
Are 1D predictions useful?
- sub-cellular localisation
- whole genomes
- 3D structure: threading
- floppy regions