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| Title: | Simple jury predicts protein secondary structure best |
| Author: | Burkhard Rost, Pierre Baldi, Geoff Barton, James Cuff, Volker A Eyrich, David Jones, Kevin Karplus, Ross King, Gianluca Pollastri & Dariusz Przybylski |
| Quote: | Preprint CUBIC_2001_10 |
The field of secondary structure prediction methods has advanced again. The best methods now reach levels of 74-76% of the residues correctly predicted in one of the three states helix, strand, or other. In context of EVA/CASP, we experimented with averaging over the best current methods. The resulting jury decision proved significantly more accurate than the best method. Although the 'jury' seemed the best choice on average, for 60% of all proteins one method was better than the jury. Furthermore, the best individual methods tended to be superior to the jury in estimating the reliability of a prediction. Hence, averaging over predictions may be the method of choice for a quick scan of large data set, while experts may profit from studying the respective method in detail.