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| Title: | Novel leverage of structural genomics |
| Author: | Jinfeng Liu, Gaetano T Montelione, Burkhard Rost |
| Quote: | Nature Biotechnology, 2007, in press |
Genome sequencing has transformed biomedical research, but it is only the first step toward understanding biological systems. Subsequent steps include the determination of three-dimensional (3D) structures and functions for all proteins, and the study of networks. One long-term goal of Structural Genomics (SG) is to make 3D atomic-level structures easily obtainable for most proteins from their corresponding DNA sequences. In particular, the Protein Structure Initiative (PSI) from the National Institutes of Health (NIH) in the USA is expanding the impact of the Human Genome Project [1] by large-scale structure determination [2] . As part of the five-year pilot phase (PSI1), more than 1,200 protein structures were deposited into the PDB [3] . The second phase of PSI (PSI2), initiated July 1, 2005, supports four Large-scale Research Centers, along with six additional Specialized Research Centers responsible for development of new technologies for structural biology and structural genomics. Structural genomics projects have also been established in Europe [4] , Japan [5] and Canada [2] .
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