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| Title: | Neural networks predict protein structure: hype or hit? |
| Author: | Burkhard Rost |
| Quote: | In 'Artificial intelligence and heuristic methods for bioinformatics' Paolo Frasconi and Ron Shamir (eds.) Amsterdam: IOS Press, 2003, 34-50 |
Neural networks have been applied to many pattern classification problems. Here, I review applications to the problem of predicting protein structure from protein sequence. Initially, many methods were apparently designed by researchers who just wanted a real-life application for their gadget. However, the competitiveness of the field separated the wheat from the chaff. Meanwhile, several neural network-based methods have contributed significantly to advancing the field of bio-informatics, and some are clearly influencing molecular biology. Today, a plethora of network methods is used in everyday sequence analysis, and an increasing number of applications explore very novel problems.