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| Title: | Structure prediction of proteins - where are we now? |
| Author: | Burkhard Rost & Chris Sander |
| Quote: | Curr.Opin. Biotech. , 5, 372-380 (1994) |
Although the structure-from-sequence prediction problem remains fundamentally unsolved, new and promising methods in 3D, 2D, and 1D have reopened the field. Pseudopotentials or information values derived from the databases can distinguish between correct and incorrect models (3D). Interresidue contacts (2D) can detected by the analysis of correlated mutations, albeit with low accuracy. Significantly improved prediction of secondary structure (1D) from multiple sequence alignments is now available in daily practice.