You have reached the new web pages of the Rost lab; we are happy about any recommendations and suggestions that will help us improve our resources. Please contact: admin. For those of you who prefer to continue using the previous layout for some time they will be available without support at http://rostlab.org/old_before2008/.

About Us

The lab's research is driven by a conviction that protein and DNA sequences encode a significant core of information about the ultimate structure and function of genetic material and its gene products. Research goals of the lab involve using protein and DNA sequences along with evolutionary information to predict a protein's: overall function, interaction partners, secondary structure, disordered regions, subcellular localization, membrane spanning protein structure, intra-chain residue contacts, cell cycle control, and domain boundaries. Another significant research focus is to improve the effectiveness and efficiency of structural genomics projects' ability to determine the structures of proteins on a large scale.

Quick Jump to CUBIC services   List of Services - PredictProtein: Sequence analysis and Protein structure Prediction - MetaPP: Common interface to a battery of public protein structure and function prediction servers - EVA: EVAluation of automatic protein structure prediction servers - AGAPE: improved and generalized method for sequence-profile and profile-profile comparisons - CHOP: CHOPping proteins into structural domain-like fragments - ConSequenceS: Consensus Sequence Searches with PSI-BLAST - DSSPcont: Continuous assignment of Protein Secondary Structure - ECGO: Prediction of Enzymatic Activity of a Protein Sequence in Terms of Enzyme Commission (EC) Numbers - MD: Protein disorder prediction based on orthogonal sources of information - NORSp: Prediction of NOn-Regular Secondary Structure (NORS) - PROFbval: Prediction of protein flexibility and rigidity prediction from sequence - PROFcon: Prediction of inter-residue contacts - PROFtmb: Prediction of TransMembrane Beta Barrels - TMH-Benchmark: Evaluate new methods for Trans-Membrane Helix prediction - Ucon - Prediction of natively unstructured regions through contact maps - DISIS: Prediction of residues involved in DNA binding - ISIS: Prediction of residues involved in external protein-protein interactions - LOCnet: De novo prediction of protein sub-cellular localization - LOCtree: Prediction of sub-cellular LOCalization for structural genomics targets - PiNat: Method for assessing the validity of yeast two hybrid experiments results - predictNLS: Prediction and analysis of Nuclear Localization Signals - SNAP: Evaluates the effects of single amino acid substitutions on protein function - UniqueProt: Creating sequence-Unique Protein databases - NLProt: Mining Natural Language text for PROTein names and their UniProt-IDs - GeneTegrate: A java based viewer for PredictProtein List of Databases - CellCycleDB: Database collecting and annotating proteins involved in cell-cycle control - CLUP: Database with clusters of CHOP fragments - Epitome: Database of structure-inferred antigenic epitopes - ERGolgiDB: Archive of proteins from endoplasmic reticulum and Golgi apparatus - NLSdb: Database of nuclear localization signals (NLSs) and of nuclear proteins targeted to the nucleus by NLS motifs - PEP: Database with alignments and predictions for 62 entirely sequenced proteomes